| NCT03401112 |
A Study of IMR-687 in Adult Patients With Sickle Cell Anaemia (Homozygous HbSS or Sickle-β0 Thalassemia) |
https://ClinicalTrials.gov/show/NCT03401112 |
Active, not recruiting |
Imara, Inc. |
2020-09-30 |
| NCT03402191 |
L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension |
https://ClinicalTrials.gov/show/NCT03402191 |
Recruiting |
Tanta University |
2023-12-31 |
| NCT03381833 |
A Study With LJPC-401 for the Treatment of Myocardial Iron Overload in Adult Patients With Transfusion-Dependent Beta Thalassemia |
https://ClinicalTrials.gov/show/NCT03381833 |
Recruiting |
La Jolla Pharmaceutical Company |
2019-10-31 |
| NCT03374111 |
Colla Corii Asini Treating Anemia in Pregnant Women With Thalassemia(Presenting the Syndrome of Blood Deficiency) |
https://ClinicalTrials.gov/show/NCT03374111 |
Recruiting |
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine |
2019-10-01 |
| NCT03367546 |
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant Diseases |
https://ClinicalTrials.gov/show/NCT03367546 |
Recruiting |
Masonic Cancer Center, University of Minnesota |
2025-11-30 |
| NCT04092205 |
Phase 2a Pilot Study of NBMI Treatment in Patients With Beta Thalassemia Major, Requiring Iron Chelation |
https://ClinicalTrials.gov/show/NCT04092205 |
Recruiting |
EmeraMed |
2020-03-30 |
| NCT04054921 |
Safety Study for Beta Thalassemia Subjects on PTG-300 |
https://ClinicalTrials.gov/show/NCT04054921 |
Recruiting |
Protagonist Therapeutics, Inc. |
2021-05-10 |
| NCT03342404 |
A Study to Determine the Efficacy and Safety of Luspatercept in Adults With Non Transfusion Dependent Beta (β)-Thalassemia |
https://ClinicalTrials.gov/show/NCT03342404 |
Active, not recruiting |
Celgene |
2020-09-14 |
| NCT03311243 |
Periodontal Therapy in Thalassemia Major Patients |
https://ClinicalTrials.gov/show/NCT03311243 |
Completed |
King Saud University |
2017-04-10 |
| NCT03275051 |
Long-term Follow-up of Subjects Treated With OTL-300 for Transfusion Dependent Beta-thalassemia Study (TIGET-BTHAL) |
https://ClinicalTrials.gov/show/NCT03275051 |
Enrolling by invitation |
Orchard Therapeutics |
2025-12-01 |
| NCT03271541 |
A Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia |
https://ClinicalTrials.gov/show/NCT03271541 |
Completed |
Hoffmann-La Roche |
2018-06-29 |
| NCT03249831 |
A Blood Stem Cell Transplant for Sickle Cell Disease |
https://ClinicalTrials.gov/show/NCT03249831 |
Recruiting |
City of Hope Medical Center |
2022-12-31 |
| NCT03176849 |
A Randomized Phase IV Control Trial of Single High Dose Oral Vitamin D3 in Pediatric Patients Undergoing HSCT |
https://ClinicalTrials.gov/show/NCT03176849 |
Enrolling by invitation |
Phoenix Children’s Hospital |
2019-09-01 |
| NCT03171831 |
Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major |
https://ClinicalTrials.gov/show/NCT03171831 |
Recruiting |
First Affiliated Hospital of Guangxi Medical University |
2021-12-31 |
| NCT03117192 |
Zinc Supplementation on Cellular Immunity in Thalassemia Major |
https://ClinicalTrials.gov/show/NCT03117192 |
Completed |
Fakultas Kedokteran Universitas Indonesia |
2014-02-01 |
| NCT03101423 |
Monitoring of Chimerism After Transplantation in Patients With β Thalassemia Major and the Treatment Strategies for the Reduction of Chimerism |
https://ClinicalTrials.gov/show/NCT03101423 |
Active, not recruiting |
First Affiliated Hospital of Guangxi Medical University |
2019-12-31 |
| NCT03095326 |
Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia |
https://ClinicalTrials.gov/show/NCT03095326 |
Completed |
Fakultas Kedokteran Universitas Indonesia |
2014-02-01 |
| NCT03032666 |
Sofosbuvir/Ledipasvir for Hepatitis C Genotype 1-6 in Patients With Transfusion-Dependent Thalassemia: An Open Label Trial |
https://ClinicalTrials.gov/show/NCT03032666 |
Completed |
American University of Beirut Medical Center |
2018-08-06 |
| NCT02998450 |
A Study of IMR-687 in Healthy Adult Volunteers |
https://ClinicalTrials.gov/show/NCT02998450 |
Completed |
Imara, Inc. |
2017-07-08 |
| NCT02993224 |
Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet |
https://ClinicalTrials.gov/show/NCT02993224 |
Active, not recruiting |
Novartis |
2021-02-26 |
| NCT02986698 |
In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) |
https://ClinicalTrials.gov/show/NCT02986698 |
Recruiting |
University of California, San Francisco |
2022-02-28 |
| NCT02984475 |
The Potential Hepatoprotective Effect of Metformin in Patients With Beta Thalassemia Major |
https://ClinicalTrials.gov/show/NCT02984475 |
Recruiting |
Cairo University |
2018-12-31 |
| NCT02950857 |
A Study of EPEG in Beta Thalassemia Patients |
https://ClinicalTrials.gov/show/NCT02950857 |
Completed |
Prolong Pharmaceuticals |
2017-09-27 |
| NCT02906202 |
A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Subjects With Transfusion-Dependent β-Thalassemia, Who do Not Have a β0/β0 Genotype |
https://ClinicalTrials.gov/show/NCT02906202 |
Active, not recruiting |
bluebird bio |
2022-02-28 |
| NCT02744560 |
Effect of Spirulina on Liver Iron Concentration in Beta Thalassemic Children With Hepatitis C |
https://ClinicalTrials.gov/show/NCT02744560 |
Completed |
Tanta University |
2017-12-31 |
| NCT02744547 |
Effect of Spirulina on Serum Hyaluronic Acid in Beta Thalassemic Children With Hepatitis C |
https://ClinicalTrials.gov/show/NCT02744547 |
Completed |
Tanta University |
2017-12-31 |
| NCT02744105 |
Effect of Spirulina on Liver Fibrosis by Transient Elastography in Beta Thalassemic Children With Hepatitis C |
https://ClinicalTrials.gov/show/NCT02744105 |
Completed |
Tanta University |
2017-12-31 |
| NCT02674607 |
the Potential Immunomodulatory Effects of Spirulina on Thalassemic Children |
https://ClinicalTrials.gov/show/NCT02674607 |
Completed |
Tanta University |
2017-10-31 |
| NCT02671695 |
Effect of Spirulina Compared to Amlodipine on Cardiac Iron Overload in Children With Beta Thalassemia |
https://ClinicalTrials.gov/show/NCT02671695 |
Completed |
Tanta University |
2018-04-30 |
| NCT02604433 |
An Efficacy and Safety Study of Luspatercept (ACE-536) Versus Placebo in Adults Who Require Regular Red Blood Cell Transfusions Due to Beta (β) Thalassemia |
https://ClinicalTrials.gov/show/NCT02604433 |
Active, not recruiting |
Celgene |
2017-11-24 |
| NCT02597595 |
Effects of Spirulina on Cardiac Functions in Children With Beta Thalassemia Major |
https://ClinicalTrials.gov/show/NCT02597595 |
Completed |
Tanta University |
2017-10-31 |
| NCT02038478 |
Allograft for Sickle Cell Disease and Thalassemia |
https://ClinicalTrials.gov/show/NCT02038478 |
Recruiting |
University of Texas Southwestern Medical Center |
2021-01-31 |
| NCT02559648 |
Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis |
https://ClinicalTrials.gov/show/NCT02559648 |
Completed |
Laikο General Hospital, Athens |
2016-12-31 |
| NCT02453477 |
Gene Therapy for Transfusion Dependent Beta-thalassemia |
https://ClinicalTrials.gov/show/NCT02453477 |
Active, not recruiting |
IRCCS San Raffaele |
2019-08-31 |
| NCT02435901 |
HSCT For Patients With High Risk Hemoglobinopathies Using Reduced Intensity |
https://ClinicalTrials.gov/show/NCT02435901 |
Active, not recruiting |
Northwell Health |
2019-01-31 |
| NCT02380079 |
Dose-Escalation Study of SCD-101 in Sickle Cell Disease |
https://ClinicalTrials.gov/show/NCT02380079 |
Recruiting |
Invenux, LLC |
2020-10-31 |
| NCT02326597 |
Decision Aid for Therapeutic Options In Sickle Cell Disease |
https://ClinicalTrials.gov/show/NCT02326597 |
Completed |
Emory University |
2017-04-17 |
| NCT02268409 |
ACE-536 Extension Study - Beta Thalassemia |
https://ClinicalTrials.gov/show/NCT02268409 |
Active, not recruiting |
Acceleron Pharma, Inc. |
2020-02-29 |
| NCT02212535 |
Assessment of Tolerance of Mobilizing Peripheral Hematopoietic Stem Cells by Plerixafor in Sickle Cell Patients |
https://ClinicalTrials.gov/show/NCT02212535 |
Completed |
Assistance Publique - Hôpitaux de Paris |
2017-04-04 |
| NCT02198508 |
Clinical Trial of Deferasirox Combination Treatment With Deferiprone In Thalassaemia Patients |
https://ClinicalTrials.gov/show/NCT02198508 |
Completed |
China Medical University Hospital |
2008-07-31 |
| NCT02179359 |
Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies |
https://ClinicalTrials.gov/show/NCT02179359 |
Recruiting |
Masonic Cancer Center, University of Minnesota |
2020-08-31 |
| NCT02165007 |
Haploidentical Hematopoietic Stem Cell Transplantation |
https://ClinicalTrials.gov/show/NCT02165007 |
Recruiting |
Children’s National Research Institute |
2022-11-30 |
| NCT02151526 |
A Study Evaluating the Safety and Efficacy of LentiGlobin BB305 Drug Product in β-Thalassemia Major (Also Referred to as Transfusion-dependent β-Thalassemia [TDT]) and Sickle Cell Disease |
https://ClinicalTrials.gov/show/NCT02151526 |
Completed |
bluebird bio |
2019-02-26 |
| NCT02133560 |
Use of Mobile Technology for Intensive Training in Medication Management |
https://ClinicalTrials.gov/show/NCT02133560 |
Completed |
Duke University |
2016-08-01 |
| NCT02105766 |
Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure |
https://ClinicalTrials.gov/show/NCT02105766 |
Recruiting |
National Institutes of Health Clinical Center (CC) |
2021-08-31 |
| NCT02072668 |
The Effect of Rivaroxaban in Sickle Cell Disease |
https://ClinicalTrials.gov/show/NCT02072668 |
Completed |
University of North Carolina, Chapel Hill |
2018-10-04 |
| NCT02065869 |
Safety Study of Gene Modified Donor T-cells Following TCR Alpha Beta Depleted Stem Cell Transplant |
https://ClinicalTrials.gov/show/NCT02065869 |
Active, not recruiting |
Bellicum Pharmaceuticals |
2020-08-31 |
| NCT02065492 |
Amlodipine for Myocardial Iron in Thalassemia |
https://ClinicalTrials.gov/show/NCT02065492 |
Completed |
Aga Khan University |
2015-10-31 |
| NCT01284738 |
Beta-thalassemia and Microparticles |
https://ClinicalTrials.gov/show/NCT01284738 |
Completed |
Assistance Publique Hopitaux De Marseille |
2014-02-28 |
| NCT02049450 |
Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia. |
https://ClinicalTrials.gov/show/NCT02049450 |
Completed |
Novartis |
2016-04-12 |
| NCT04364269 |
Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Preliminary Efficacy of VIT-2763 in β-thalassaemia |
https://ClinicalTrials.gov/show/NCT04364269 |
Recruiting |
Vifor (International) Inc. |
2021-05-31 |
| NCT03825341 |
Hydroxyurea Therapy: Optimizing Access in Pediatric Populations Everywhere |
https://ClinicalTrials.gov/show/NCT03825341 |
Recruiting |
St. Jude Children’s Research Hospital |
2021-06-30 |
| NCT01966367 |
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation |
https://ClinicalTrials.gov/show/NCT01966367 |
Active, not recruiting |
Columbia University |
2022-01-31 |
| NCT01960413 |
Phase 2 Study of Montelukast for the Treatment of Sickle Cell Anemia |
https://ClinicalTrials.gov/show/NCT01960413 |
Completed |
Vanderbilt University Medical Center |
2018-03-31 |
| NCT01917708 |
Bone Marrow Transplant With Abatacept for Non-Malignant Diseases |
https://ClinicalTrials.gov/show/NCT01917708 |
Completed |
Emory University |
2019-09-19 |
| NCT00006136 |
Phase II Study of Arginine Butyrate With or Without Epoetin Alfa in Patients With Thalassemia Intermedia |
https://ClinicalTrials.gov/show/NCT00006136 |
Completed |
Office of Rare Diseases (ORD) |
NA |
| NCT01863173 |
Effect of Metoprolol on Thalassemia Cardiomyopathy |
https://ClinicalTrials.gov/show/NCT01863173 |
Completed |
Shiraz University of Medical Sciences |
2012-05-31 |
| NCT01772680 |
Zinc and Diabetes in Patients With Thalassemia: a Pilot Study |
https://ClinicalTrials.gov/show/NCT01772680 |
Completed |
UCSF Benioff Children’s Hospital Oakland |
2015-01-31 |
| NCT01758042 |
Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders |
https://ClinicalTrials.gov/show/NCT01758042 |
Recruiting |
Massachusetts General Hospital |
2019-07-31 |
| NCT01749540 |
Study to Evaluate the Effects of ACE-536 in Patients With Beta-thalassemia |
https://ClinicalTrials.gov/show/NCT01749540 |
Completed |
Acceleron Pharma, Inc. |
2015-11-30 |
| NCT00004378 |
Stem Cell Transplantation (SCT) for Genetic Diseases |
https://ClinicalTrials.gov/show/NCT00004378 |
Completed |
National Center for Research Resources (NCRR) |
NA |
| NCT01745120 |
A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants |
https://ClinicalTrials.gov/show/NCT01745120 |
Completed |
bluebird bio |
2018-02-08 |
| NCT01740531 |
Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion |
https://ClinicalTrials.gov/show/NCT01740531 |
Completed |
Cerus Corporation |
2017-12-21 |
| NCT01736540 |
An Epidemiological Study to Assess Iron Overload Using MRI in Patients With Transfusional Siderosis (TIMES Study) |
https://ClinicalTrials.gov/show/NCT01736540 |
Completed |
Novartis |
2015-05-31 |
| NCT01709838 |
Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent Thalassemia |
https://ClinicalTrials.gov/show/NCT01709838 |
Completed |
Novartis |
2015-01-03 |
| NCT01709032 |
Combination Deferasirox and Deferiprone for Severe Iron Overload in Thalassemia |
https://ClinicalTrials.gov/show/NCT01709032 |
Completed |
Children’s Hospital of Philadelphia |
2015-08-01 |
| NCT01642758 |
Trial of HQK-1001 in Beta Thalassemia Intermedia in Lebanon |
https://ClinicalTrials.gov/show/NCT01642758 |
Completed |
Boston University |
2012-11-30 |
| NCT01610297 |
Post Hematopoietic Stem Cell Transplantation |
https://ClinicalTrials.gov/show/NCT01610297 |
Completed |
Novartis |
2015-10-31 |
| NCT01609595 |
Study of SDMB (2,2 Dimethylbutyrate, Sodium Salt) in Beta Thalassemia Intermedia in Thailand |
https://ClinicalTrials.gov/show/NCT01609595 |
Completed |
Boston University |
2012-11-30 |
| NCT01597765 |
Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E Patients |
https://ClinicalTrials.gov/show/NCT01597765 |
Completed |
Mahidol University |
2011-06-30 |
| NCT01590628 |
Allogeneic SCT of NiCord®, UCB-Derived Ex Vivo Expanded Stem and Progenitor Cells, in Patients With Hemoglobinopathies |
https://ClinicalTrials.gov/show/NCT01590628 |
Active, not recruiting |
Gamida Cell ltd |
2019-09-30 |
| NCT01571635 |
Study to Determine the Safety and Tolerability of Sotatercept (ACE-011) in Adults With Beta( β)- Thalassemia. |
https://ClinicalTrials.gov/show/NCT01571635 |
Active, not recruiting |
Celgene |
2015-07-02 |
| NCT01395199 |
Amlodipine in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major |
https://ClinicalTrials.gov/show/NCT01395199 |
Completed |
University of Campinas, Brazil |
2015-02-28 |
| NCT01369719 |
Efficacy and Safety of Desferal Versus Osveral in Transfusional Iron Overload |
https://ClinicalTrials.gov/show/NCT01369719 |
Completed |
Hormozgan University of Medical Sciences |
2011-01-31 |
| NCT04390971 |
Safety and Efficacy Evaluation of ET-01 Transplantation in Subjects With Transfusion Dependent β-Thalassaemia |
https://ClinicalTrials.gov/show/NCT04390971 |
Recruiting |
Institute of Hematology & Blood Diseases Hospital |
2021-10-31 |
| NCT04353986 |
PK of SOF/LED in HCV - Infected Adolescents With Haematological Disorders |
https://ClinicalTrials.gov/show/NCT04353986 |
Recruiting |
Ain Shams University |
2020-04-30 |
| NCT04292314 |
Hydroxy Urea, Omega 3, Nigella Sativa,Honey on Oxidative Stress and Iron Chelation in Pediatric Major Thalassemia |
https://ClinicalTrials.gov/show/NCT04292314 |
Recruiting |
Beni-Suef University |
2020-10-31 |
| NCT04260516 |
The Effect of N-acetylcysteine on Oxidative Stress Status and Iron Overload in Thalassemia Major |
https://ClinicalTrials.gov/show/NCT04260516 |
Completed |
Beni-Suef University |
2019-12-03 |
| NCT04211480 |
Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem Cells |
https://ClinicalTrials.gov/show/NCT04211480 |
Recruiting |
Shanghai Bioray Laboratory Inc. |
2021-05-30 |
| NCT04090268 |
Precision Exercise in Children With Malignant Hemopathies |
https://ClinicalTrials.gov/show/NCT04090268 |
Recruiting |
University of Milano Bicocca |
2021-04-03 |
| NCT04064060 |
A Study to Evaluate Long-term Safety in Subjects Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials |
https://ClinicalTrials.gov/show/NCT04064060 |
Recruiting |
Celgene |
2028-01-24 |
| NCT04009525 |
Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study |
https://ClinicalTrials.gov/show/NCT04009525 |
Recruiting |
First Affiliated Hospital of Guangxi Medical University |
2022-05-31 |
| NCT03993613 |
Apotransferrin in Patients With β-thalassemia |
https://ClinicalTrials.gov/show/NCT03993613 |
Recruiting |
Sanquin Plasma Products BV |
2020-05-01 |
| NCT03992001 |
Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients |
https://ClinicalTrials.gov/show/NCT03992001 |
Enrolling by invitation |
Università degli Studi di Ferrara |
2019-06-30 |
| NCT03961828 |
Hyalornic Acid Level in β-Thalassemic Children Treated for Hepatitis C Virus |
https://ClinicalTrials.gov/show/NCT03961828 |
Completed |
Tanta University |
2018-12-31 |
| NCT03948737 |
The Effect of Alpha-tocopherol in Hemolysis and Oxidative Stress Marker on the Red Cell Membrane Beta-thalassemia Major |
https://ClinicalTrials.gov/show/NCT03948737 |
Completed |
Indonesia University |
2017-07-30 |
| NCT03935633 |
Short-term Clinical Study of CN128 in Thalassemia Patients |
https://ClinicalTrials.gov/show/NCT03935633 |
Completed |
Hangzhou Zede Pharma-Tech Co., Ltd. |
2019-05-06 |
| NCT03919812 |
Immunomodulatory Vitamin D in Thalassemia |
https://ClinicalTrials.gov/show/NCT03919812 |
Completed |
Universitas Padjadjaran |
2018-07-15 |
| NCT03889977 |
Resistance Exercise on Postprandial Hyperglycemia in Patients With B-thalassemia Exhibiting Resistance to Insulin |
https://ClinicalTrials.gov/show/NCT03889977 |
Completed |
University of Thessaly |
2019-08-30 |
| NCT03877809 |
Testing SIROLIMUS in Beta-thalassemia Transfusion Dependent Patients |
https://ClinicalTrials.gov/show/NCT03877809 |
Recruiting |
Rare Partners srl Impresa Sociale |
2020-09-30 |
| NCT03851055 |
Zinc Supplementation in Patients With β-Thalassemia Major Complicated With Diabetes Mellitus |
https://ClinicalTrials.gov/show/NCT03851055 |
Completed |
Ain Shams University |
2018-07-10 |
| NCT03802201 |
Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia |
https://ClinicalTrials.gov/show/NCT03802201 |
Recruiting |
Protagonist Therapeutics, Inc. |
2020-08-31 |
| NCT03763656 |
Pharmacokinetics of Oral Hydroxyurea Solution |
https://ClinicalTrials.gov/show/NCT03763656 |
Recruiting |
Nova Laboratories Limited |
2021-01-31 |
| NCT03733249 |
Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study |
https://ClinicalTrials.gov/show/NCT03733249 |
Enrolling by invitation |
Bellicum Pharmaceuticals |
2034-06-30 |
| NCT03692052 |
A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AG-348 in Adult Participants With Non-transfusion-dependent Thalassemia |
https://ClinicalTrials.gov/show/NCT03692052 |
Active, not recruiting |
Agios Pharmaceuticals, Inc. |
2022-08-28 |
| NCT03673085 |
Clinical Study of CN128 in Thalassemia Patients |
https://ClinicalTrials.gov/show/NCT03673085 |
Completed |
Hangzhou Zede Pharma-Tech Co., Ltd. |
2018-10-16 |
| NCT03655678 |
A Safety and Efficacy Study Evaluating CTX001 in Subjects With Transfusion-Dependent β-Thalassemia |
https://ClinicalTrials.gov/show/NCT03655678 |
Recruiting |
Vertex Pharmaceuticals Incorporated |
2021-02-28 |
| NCT03653338 |
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias |
https://ClinicalTrials.gov/show/NCT03653338 |
Recruiting |
University of Pittsburgh |
2023-08-01 |
| NCT03651102 |
Efficacy and Safety of Low Dose Thalidomide in Transfusion Dependent Thalassemia |
https://ClinicalTrials.gov/show/NCT03651102 |
Recruiting |
Blood Diseases Clinic |
2020-08-30 |
| NCT03637556 |
Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation |
https://ClinicalTrials.gov/show/NCT03637556 |
Recruiting |
DisperSol Technologies, LLC |
2020-07-31 |
| NCT03591900 |
The Use of CGMS to Detect Alterations of Blood Glucose in Thalassemic Patients |
https://ClinicalTrials.gov/show/NCT03591900 |
Completed |
Ain Shams University |
2016-06-30 |
| NCT03591575 |
Safety and Efficacy of Early Treatment With Deferiprone in Infants and Young Children |
https://ClinicalTrials.gov/show/NCT03591575 |
Active, not recruiting |
Chiesi Canada Corp |
2020-11-01 |
| NCT03513328 |
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation |
https://ClinicalTrials.gov/show/NCT03513328 |
Recruiting |
University of Florida |
2021-06-30 |
| NCT03432364 |
A Study to Assess the Safety, Tolerability, and Efficacy of ST-400 for Treatment of Transfusion-Dependent Beta-thalassemia (TDT) |
https://ClinicalTrials.gov/show/NCT03432364 |
Active, not recruiting |
Sangamo Therapeutics |
2021-03-31 |
| NCT01250951 |
This Study Will Evaluate Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndromes (MDS), Thalassemia and Rare Anemia Types Having Transfusion-induced Iron Overload. |
https://ClinicalTrials.gov/show/NCT01250951 |
Completed |
Novartis |
2011-07-31 |
| NCT01224496 |
Traditional Chinese Medicine in the Supportive Management of Anaemic and Cytopenic (Leukopenia, Thrombocytopenia) Haematological Disorders |
https://ClinicalTrials.gov/show/NCT01224496 |
Completed |
Singapore General Hospital |
2011-08-31 |
| NCT01206075 |
Evaluating the Safety and Effectiveness of Mozobil Mobilization in Adults With Beta-Thalassemia Major |
https://ClinicalTrials.gov/show/NCT01206075 |
Completed |
University of Washington |
2012-12-31 |
| NCT01186419 |
Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload |
https://ClinicalTrials.gov/show/NCT01186419 |
Completed |
Shire |
2012-12-31 |
| NCT01179217 |
A Phase III Safety and Efficacy Study of L-Glutamine to Treat Sickle Cell Disease or Sickle βo-thalassemia |
https://ClinicalTrials.gov/show/NCT01179217 |
Completed |
Emmaus Medical, Inc. |
2014-03-31 |
| NCT01140321 |
Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI |
https://ClinicalTrials.gov/show/NCT01140321 |
Completed |
Ente Ospedaliero Ospedali Galliera |
2010-05-31 |
| NCT01125254 |
Amlodipine Use in the Prevention and Treatment of Iron Overload in Patients With Thalassemia Major |
https://ClinicalTrials.gov/show/NCT01125254 |
Completed |
University of Campinas, Brazil |
2011-07-31 |
| NCT01049854 |
CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant |
https://ClinicalTrials.gov/show/NCT01049854 |
Completed |
New York Medical College |
2017-11-30 |
| NCT01048905 |
Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension |
https://ClinicalTrials.gov/show/NCT01048905 |
Completed |
UCSF Benioff Children’s Hospital Oakland |
2014-03-31 |
| NCT01039636 |
Safety and Pharmacokinetic Study of Escalating Multiple Doses of an Iron Chelator in Patients With Iron Overload |
https://ClinicalTrials.gov/show/NCT01039636 |
Completed |
FerroKin BioSciences, Inc. |
2010-12-31 |
| NCT01005576 |
Reduced Intensity Transplant Conditioning Regimen for Severe Thalassemia |
https://ClinicalTrials.gov/show/NCT01005576 |
Completed |
Washington University School of Medicine |
2014-04-30 |
| NCT00957931 |
Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs |
https://ClinicalTrials.gov/show/NCT00957931 |
Completed |
Stanford University |
2013-08-31 |
| NCT00901199 |
Combo Chelation Trial |
https://ClinicalTrials.gov/show/NCT00901199 |
Completed |
UCSF Benioff Children’s Hospital Oakland |
2012-10-31 |
| NCT00879242 |
Effect of Deferasirox on Patients With Cardiac MRI T2* < 20 Msec |
https://ClinicalTrials.gov/show/NCT00879242 |
Completed |
Novartis |
2011-05-31 |
| NCT00873041 |
Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study |
https://ClinicalTrials.gov/show/NCT00873041 |
Completed |
Novartis |
2011-06-30 |
| NCT00872170 |
Sildenafil to Improve Exercise Capacity in People With Thalassemia and Pulmonary Hypertension |
https://ClinicalTrials.gov/show/NCT00872170 |
Completed |
HealthCore-NERI |
2010-06-30 |
| NCT00809042 |
Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia Intermedia |
https://ClinicalTrials.gov/show/NCT00809042 |
Completed |
Shiraz University of Medical Sciences |
2007-11-30 |
| NCT03207009 |
A Study Evaluating the Efficacy and Safety of the LentiGlobin® BB305 Drug Product in Subjects With Transfusion-Dependent β-Thalassemia |
https://ClinicalTrials.gov/show/NCT03207009 |
Recruiting |
bluebird bio |
2022-06-30 |
| NCT03333486 |
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer |
https://ClinicalTrials.gov/show/NCT03333486 |
Recruiting |
Roswell Park Cancer Institute |
2022-09-06 |
| NCT03165864 |
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS 702843 Administered Subcutaneously to Healthy Volunteers |
https://ClinicalTrials.gov/show/NCT03165864 |
Completed |
Ionis Pharmaceuticals, Inc. |
2018-09-25 |
| NCT01639690 |
ß-Thalassemia Major With Autologous CD34+ Hematopoietic Progenitor Cells Transduced With TNS9.3.55 a Lentiviral Vector Encoding the Normal Human ß-Globin Gene |
https://ClinicalTrials.gov/show/NCT01639690 |
Active, not recruiting |
Memorial Sloan Kettering Cancer Center |
2021-07-31 |
| NCT04143724 |
Study of Safety & PK of Luspatercept (ACE-536) in Pediatric Subjects Who Require Regular RBC Transfusions Due to Beta (β)-Thalassemia. |
https://ClinicalTrials.gov/show/NCT04143724 |
Recruiting |
Celgene |
2021-12-04 |
| NCT00790127 |
Phase 1/2 Study of HQK-1001 in Patients With Beta Thalassemia |
https://ClinicalTrials.gov/show/NCT00790127 |
Completed |
HemaQuest Pharmaceuticals Inc. |
2010-05-31 |
| NCT00800761 |
Intensive Combined Chelation Therapy for Iron-Induced Cardiac Disease in Patients With Thalassemia Major |
https://ClinicalTrials.gov/show/NCT00800761 |
Completed |
Ospedale Microcitemico |
2006-06-30 |
| NCT00749515 |
Pilot Study for Patients With Poor Response to Deferasirox |
https://ClinicalTrials.gov/show/NCT00749515 |
Completed |
Boston Children’s Hospital |
2008-10-31 |
| NCT00744692 |
Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders |
https://ClinicalTrials.gov/show/NCT00744692 |
Completed |
Duke University |
2012-12-31 |
| NCT00733811 |
Efficacy Study of the Use of Sequential DFP-DFO Versus DFP |
https://ClinicalTrials.gov/show/NCT00733811 |
Completed |
Azienda Ospedaliera V. Cervello |
2008-01-31 |
| NCT00730314 |
Unrelated Hematopoietic Stem Cell Transplantation(HSCT) for Genetic Diseases of Blood Cells |
https://ClinicalTrials.gov/show/NCT00730314 |
Completed |
Children’s Hospital Los Angeles |
2015-08-31 |
| NCT00712738 |
Oral Nifedipine to Treat Iron Overload |
https://ClinicalTrials.gov/show/NCT00712738 |
Completed |
National Institutes of Health Clinical Center (CC) |
2010-09-22 |
| NCT00707850 |
Pegasys® Plus Ribavirin in Thalassemic Patients With Hepatitis C Virus Infection |
https://ClinicalTrials.gov/show/NCT00707850 |
Completed |
Baqiyatallah Medical Sciences University |
2009-09-30 |
| NCT00661726 |
Evaluating the Safety and Effectiveness of Decitabine in People With Thalassemia Intermedia |
https://ClinicalTrials.gov/show/NCT00661726 |
Completed |
HealthCore-NERI |
2010-05-31 |
| NCT00658385 |
Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia Major |
https://ClinicalTrials.gov/show/NCT00658385 |
Completed |
Memorial Sloan Kettering Cancer Center |
2011-02-28 |
| NCT00586209 |
L-Glutamine Therapy for Sickle Cell Anemia |
https://ClinicalTrials.gov/show/NCT00586209 |
Completed |
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center |
2009-01-31 |
| NCT00564941 |
Evaluating the Efficacy of Deferasirox in Transfusion Dependent Chronic Anaemias (Myelodysplastic Syndrome, Beta-thalassaemia Patients) With Chronic Iron Overload |
https://ClinicalTrials.gov/show/NCT00564941 |
Completed |
Novartis |
2011-07-31 |
| NCT00560820 |
Phase I Study to Examine the Effect of Deferasirox on Renal Hemodynamics in β-thalassemia Patients With Transfusional Iron Overload |
https://ClinicalTrials.gov/show/NCT00560820 |
Completed |
Novartis |
2012-04-30 |
| NCT00512226 |
Iron Overload Assesment in Sickle Cell Anemia and Sickle Cell Thalassemia |
https://ClinicalTrials.gov/show/NCT00512226 |
Completed |
HaEmek Medical Center, Israel |
2010-12-31 |
| NCT00502788 |
Evaluating the Safety of Two Medications to Treat Hepatitis C in People With Thalassemia (The HepC Study) |
https://ClinicalTrials.gov/show/NCT00502788 |
Completed |
HealthCore-NERI |
2006-06-30 |
| NCT00459732 |
Zinc & Bone Health in Thalassemia: The Think Zinc Study |
https://ClinicalTrials.gov/show/NCT00459732 |
Completed |
UCSF Benioff Children’s Hospital Oakland |
2009-10-31 |
| NCT00456690 |
Endocrine and Nutritional Assessment in B Thalassemia Major |
https://ClinicalTrials.gov/show/NCT00456690 |
Completed |
HaEmek Medical Center, Israel |
2014-12-31 |
| NCT00447694 |
Cardiac T2* in Beta-thalassemia Patients on Deferasirox Treatment |
https://ClinicalTrials.gov/show/NCT00447694 |
Completed |
Novartis |
2009-11-30 |
| NCT00427661 |
A Pilot Study of HSCT for Patients With High-risk Hemoglobinopathy Using a Nonmyeloablative Preparative Regimen |
https://ClinicalTrials.gov/show/NCT00427661 |
Completed |
University of Pittsburgh |
2014-05-31 |
| NCT00408447 |
Stem Cell Transplant in Sickle Cell Disease and Thalassemia |
https://ClinicalTrials.gov/show/NCT00408447 |
Active, not recruiting |
Columbia University |
2019-08-06 |
| NCT00390858 |
A 4-year Extension Study to Core 1-year Study of Iron Chelation Therapy With Deferasirox in β-thalassemia Major Pediatric Patients With Transfusional Iron Overload. |
https://ClinicalTrials.gov/show/NCT00390858 |
Completed |
Novartis |
2008-02-29 |
| NCT00346242 |
Evaluation of Efficacy of Zoledronic Acid in Patients With Haemoglobin Syndromes (Thalassemia and Sicle Cell Anaemia) and Risk of Skeletal Events |
https://ClinicalTrials.gov/show/NCT00346242 |
Completed |
Novartis |
2006-03-31 |
| NCT00336362 |
Evaluating the Safety of G-CSF Mobilization in Individuals With Beta Thalassemia Major |
https://ClinicalTrials.gov/show/NCT00336362 |
Completed |
University of Washington |
2010-08-31 |
| NCT00235391 |
Expanded Access of Deferasirox to Patients With Congenital Disorders of Red Blood Cells and Chronic Iron Overload |
https://ClinicalTrials.gov/show/NCT00235391 |
Completed |
Novartis |
2008-10-31 |
| NCT00176852 |
Stem Cell Transplant for Hemoglobinopathy |
https://ClinicalTrials.gov/show/NCT00176852 |
Completed |
Masonic Cancer Center, University of Minnesota |
2014-03-31 |
| NCT00171301 |
Extension Study of the Efficacy and Safety of Deferasirox Treatment in Beta-thalassemia Patients With Transfusional Hemosiderosis (Study Amended to 2-year Duration) |
https://ClinicalTrials.gov/show/NCT00171301 |
Completed |
Novartis |
2008-05-31 |
| NCT00171210 |
An Extension Study of Iron Chelation Therapy With Deferasirox (ICL670) in β-thalassemia Patients With Transfusional Iron Overload |
https://ClinicalTrials.gov/show/NCT00171210 |
Completed |
Novartis |
2008-04-30 |
| NCT00171171 |
A Study of Long-term Treatment With Deferasirox in Patients With Beta-thalassemia and Transfusional Hemosiderosis |
https://ClinicalTrials.gov/show/NCT00171171 |
Completed |
Novartis |
2006-11-30 |
| NCT00153985 |
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies |
https://ClinicalTrials.gov/show/NCT00153985 |
Completed |
Dana-Farber Cancer Institute |
2008-03-31 |
| NCT00125788 |
L-Glutamine Therapy for Sickle Cell Anemia and Sickle ß0 Thalassemia |
https://ClinicalTrials.gov/show/NCT00125788 |
Completed |
Emmaus Medical, Inc. |
2008-07-31 |
| NCT00105495 |
Efficacy Study in Removing Excess Iron From the Heart |
https://ClinicalTrials.gov/show/NCT00105495 |
Completed |
ApoPharma |
NA |
| NCT00069862 |
Iron Balance Study of DFO and GT56-252 in Patients With Transfusional Iron Overload Secondary to Beta-Thalassemia |
https://ClinicalTrials.gov/show/NCT00069862 |
Completed |
Sanofi |
NA |
| NCT00061763 |
Study of Deferasirox in Iron Overload From Beta-thalassemia Unable to be Treated With Deferoxamine or Chronic Anemias |
https://ClinicalTrials.gov/show/NCT00061763 |
Completed |
Novartis |
2004-11-30 |
| NCT00061750 |
Safety & Efficacy of ICL670 vs. Deferoxamine in Beta-thalassemia Patients With Iron Overload Due to Blood Transfusions |
https://ClinicalTrials.gov/show/NCT00061750 |
Completed |
Novartis |
2004-11-30 |
| NCT00029380 |
Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia |
https://ClinicalTrials.gov/show/NCT00029380 |
Completed |
National Heart, Lung, and Blood Institute (NHLBI) |
2006-08-31 |
| NCT00303329 |
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia Patients |
https://ClinicalTrials.gov/show/NCT00303329 |
Completed |
Novartis |
2008-10-31 |
| NCT00005934 |
5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia |
https://ClinicalTrials.gov/show/NCT00005934 |
Completed |
National Institutes of Health Clinical Center (CC) |
NA |
| NCT00005893 |
Study of Allogeneic Bone Marrow Transplantation Using Matched, Related Donors in Patients With Nonmalignant Hematologic Disorders |
https://ClinicalTrials.gov/show/NCT00005893 |
Completed |
Office of Rare Diseases (ORD) |
NA |
| NCT00004982 |
Combination Iron Chelation Therapy |
https://ClinicalTrials.gov/show/NCT00004982 |
Completed |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
NA |
| NCT00001958 |
Hydroxyurea to Treat Beta-Thalassemia (Cooley’s Anemia) |
https://ClinicalTrials.gov/show/NCT00001958 |
Completed |
National Institutes of Health Clinical Center (CC) |
NA |
| NCT00000595 |
Evaluation of Subcutaneous Desferrioxamine as Treatment for Transfusional Hemochromatosis |
https://ClinicalTrials.gov/show/NCT00000595 |
Completed |
National Heart, Lung, and Blood Institute (NHLBI) |
NA |
| NCT00000588 |
Chelation Therapy of Iron Overload With Pyridoxal Isonicotinoyl Hydrazone |
https://ClinicalTrials.gov/show/NCT00000588 |
Completed |
Case Western Reserve University |
NA |